Process Analytical Technology, abbreviated PAT, is a framework presented by the American Food and Drug Administration in 2004. The intention of the framework is to encourage supervising the design, analysis, and quality control of pharmaceuticals and food to ensure final product quality.
The PAT framework operates by monitoring and adjusting the Critical Process Parameters (CCP) in order to identify and control the Critical Quality Attributes (CQA). By defining the CPPs and accordingly monitoring them in a timely manner e.g. in-line, one begins to understand the process and will be more sufficient in testing while at the same time reducing over-processing, enhancing consistency, and minimizing rejects.
In order for the PAT to contribute to maintaining good quality control, you need high-quality data. These data can be obtained by a near-infrared (NIR) spectrometer.